Abstract
Hydrazides of 4-nitro- or 3, 4-methylenedioxyhippuric acid were respectively condensed with α-methyl-β-(3, 4-methylenedioxyphenyl)-ethylamine into acid amides and by cyclization with POCl3, two kinds of imidazoisoquinoline derivatives with 2 molecules dehydrated were obtained as 9, 10-methylenedioxy-3-(4′-nitrophenyl)-5-methyl-5, 6-dihydrobenzoglyoxalocoline and 9, 10-methylenedioxy-3-(3′, 4′-methylenedioxyphenyl)-5-methyl-5, 6-dihydrobenzoglyoxalocoline. The latter acid amide was also obtained in a good yield by the fusion of the above-mentioned amine and ethyl 3, 4-methylenedioxyhippurate.An acid amide was obtained by the condensation of α-methyl-β-(3, 4-methylenedioxyphenyl)-β-methoxyethylamine and 3, 4-dimethoxyhippuric acid azide, and cyclized, but it is unknown whether two molecules were dehydrated.
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