フェノキサゾン化合物の生体物理化学的研究 (第4報)

Abstract

The apparent membrane constant f* was measured employing the Bovine eye lens capsule and the value of f* was observed to decrease in the lapse of permeation period, in the case of permeation of inorganic electrolytes, e. g., sodium chloride and also the influence of phenoxazone compounds to capsule was examined. The results are:1) When sodium chloride was employed for the permeation of the membrane, the value of f* decreased rapidly within 1-2 hours and it became constant in 4-6 hours.2) When the capsule was dipped beforehand in catalin solution, one of the phenoxazone compounds, and the permeation was carried out with sodium chloride solution, the value of f* decreased but the value of the velocity constant of membrane aging (k) become smaller, compared with the case of 1).3) After the treatment with catalin and C-catalin for 1, 2, 4 and 6 hours, two hours' permeation with sodium chloride solution was carried out. The values of f* became greater as the permeation period was longer but any difference of the value has not been found with the sample pre-treated for more than 4 hours.