Abstract
Chemotherapeutic values of the following were examined: p-Sulfanilamido-thiocyano-benzene (I), p-sulfanilamido-m-methylthiocyanobenzene (II), p-sulfanilamido-o-methyl-thiocyanobenzene (III), p-sulfanilamido-o-carbomethoxythiocyanobenzene (IV), p-sulfanilamido-o-carbethoxythiocyanobenzene (V), 2-sulfanilamido-6-methylbenzothiazole (VI) and p-sulfanilamido-iodobenzene (VII).1) (I), (II), (III) and (VII) showed a powerful growth-inhibition in vitro against coccal bacteria, the action not being antagonized by p-aminobenzoic acid.2) The toxicities of the acylated compounds of p-thiocyanoaniline were found to be different according to the kind of the acyl group present, the tolerable doze against mice being 2mg. in acetyl, 20mg. in benzoyl, and 30-50mg. in sulfanilyl compounds.3) The sulfanomides of thiocyano series showed some promising results in therapeutic tests against induced pneumococcal infection in mice.
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