Abstract
The extent of binding of digitoxin and its metabolites to bovine albumin or rat serum was determined by the method of equilibrium dialysis or ultrafiltration. The results were as follows:1) It was found that the binding effect of bovine albumin or rat serum was most marked with digitoxigenin monodigitoxoside, less with digitoxin and digitoxigenin didigitoxoside, and least with digoxin.2) With increasing concentration of digitoxin, digitoxigenin didigitoxoside or didigitoxigenin monodigitoxoside the binding proportion decreased.3) In a phosphate buffer of pH 6.4-9.2, there was no obvious effect of pH on the drug-protein binding.
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