Abstract
A series of 3-methyl-substituted 6,8-dimethylthiazolo[2,3-f]xanthines have been synthesized using 3-(chloromethyl)-6,8-dimethylthiazolo[2,3-f]xantine and various nucleophiles (primary aromatic amines, hydrasine hydrate, and mercapto derivatives). The target 3-methyl-substituted thiazoloxantines were obtained with 42 - 90% yields. The structures were determined using IR, 1 H NMR, and mass spectrometry. Most synthesized compound exhibit weak antimicrobial action with respect to C. albicans , E. coli , S. marcencens , C. freundii , Vibrion , V. anthracoides , Klebsiellae spp., Ps. aeruginosa , St. aureus , and Schigellae spp. Comparatively high inhibiting action (MPC, 0.62 and 12.5 mg/ml) on the growth of microbial cultures was observed for 3-(hydrazinomethyl)-6,8-dimethylthiazolo[2,3-f]xantine.
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