肝臓の造血成分に関する研究(第3報)原子爆弾症に対する効果

Abstract

The present paper deals with the effect of a bovine liver extract upon the recovery in blood-pictures of several serious cases and in blood and bone marrow-picture of one typically serious case. The liver extract used has been prepared by a following procedure; extract an autolyzed liver with water, add ethanol to make its concentration 70 per cent, concentrate the alecoholie solution in vacuo, and dilute a syrup obtained so as to make 1cc of the resultant solution to correspond to five grams fresh liver. The comparison between serious cases administered with the liver extract and those without added it has been made of the changes in hemoglobin concentration, red blood cell count and white blood cell count which were observed during stay in the hospital until 30 Sept., 1945 (55 days elapsed after the bombardment). It will be seen from Table 3 that the liver extract was as much effective as the blood-transfusion in increasing the rate of increase in W. B. C. It is also of interest that a simultaneous treatment with both the liver extract and the blood-transfusion gave rise to an outstanding effect in increasing W. B. C. The examination of blood-and bone marrow-picture of one serious case revealed that the intra-muscular administration of the liver extract was effective in curing a critical stage of a serious type in contrast to some other critical cases which did not receive the liver extract. The change in bone marrow during the treatment with the liver extract is as follows. Nearly complete destruction of bone marrow tissue was observed on 32 nd day after the bombardment; the recovery of R. B. C. system as well as W. B. C. system was under way on 53 rd day (20cc of the liver extract having been administered); mother cells of R. B. C., W. B. C. and blood platelets, and their mature forns were found on 76 th day when 40cc of the liver extract had been administered. From the above results of the clinical examiuations it can be postulated that the liver extract most probably influcence directly on the regeneration or reactivation of bone marrow tissue. Furthermore, the work recently reported by Carter et al. of the effect of vitamin B12 upon leukopenia produced by irradiation of X-ray, seems to suggest that the active principle effective to the regeneration of W. B. C. in the atomic bomb-disease will not be vitamin B12. (From Laboratory of Internal Medicine and of Fishery Chemistry of the Kyushu University)