Abstract
Examination of in vitro antibacterial power of isonicotinylglycine hydrazide against tubercle bacilli showed that the compound also possessed a fair amount of antibacterial action against human tubercle bacilli and, therefore, such actions were examined with various hydrazides. The samples were divided into aliphatic, aromatic, and heterocyclic compounds, and few of each group were tested. Special attention was paid to compounds containing glycine and it was found that the antibacterial action of heterocyclic compounds, especially those of pyridine series, were found to be the greatest. Aromatic compounds were found to be the next, and the aliphatic compounds possessed a very weak action. The culture medium used was a modified Kirchner medium and the strains used were H37Rv, Aoyama B, Takagaki and H2 strains of human type, Minowa strain of bovine type, and Takeo strain of avian type tubercle bacilli.
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