実験的動脈硬化症の研究(第2報) : Estrogen投与によるCholesterol飼養家鶏の腦内小動脈, 腎内小動脈及び冠動脈の動脈硬化性病変の抑制について

Abstract

While considerable attention has been given to the effects of hypercholesterolemia on the aorta and coronary vessels, limited work has deen done on the tendency to lipid infiltration of the cerebral arteries. In the present study I have given particular attention to the effects of cholesterol feeding on the tendency to lipid infiltration of the cerebral arteries, and have examined the effect of estrogen adminisrtation on these and other arteries.Chicks receiving a normal mash diet showed no arterial fatty infiltration or atheroma. When the diet was supplemented for 8 weeks with 2 per cent cholesterol and 5 per cent cottonseed oil, hypercholesterolemia resulted and lipid infiltrations were observed grossly as well as microscopically in the aorta. Lipid in filtration in the arteries of brain, heart, kidney, liver and spleen was also demonstrated. However, the intrapulmonary arteries showed no atherosclerotic chahges.Administration of estrogen to chicks on this cholesterolised diet resulted in a somewhat higher cholesterolemia and a more marked lipid infiltration of the aorta. However, the intima of the coronary arteries was free from fatty infiltrations. The intracerebral arteries and intrarenal arteries showed similar marked reduction in lipid infilration. The arteries of liver and spleen remained unprotected.