Abstract
1. 1. α 2- Adrenoceptor antagonists [ 3H]yohimbine and [ 3H]RX 781094 and the partial α 2- agonist [ 3H]clonidine exhibited specific binding to plasma membrane fragments isolated from interscapular brown fat of 7-day-old rats. 2. 2. Competition studies with epinephrine, yohimbine and practolol revealed that [ 3H]norepinephrine, the principal in vivo agonist acting upon brown adipocytes, can readily bind to α 2- adrenoceptors in brown fat of infant rats. 3. 3. The presence of α 2- adrenoceptor subclass in brown fat of infant rats may play a role in the sympathetic regulation of this rapidly proliferating tissue.
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