Abstract
JM Gaffin, BA Raby, CR Petty. Clin Exp Allergy. 2014;44(5):681–689 The B2-adrenergic receptor (B2AR) is the major target of β-agonist bronchodilators. The gene encoding the B2AR ( ADRB2 ) has been mapped to chromosome 5q31-33, a region identified as a susceptibility locus for asthma or atopy. Epigenetic changes are heritable changes in gene expression, not encoded by DNA sequence changes (eg, methylation of cytosine-phosphate guanine [CpG] islands within regulatory regions of DNA). A variably …
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