Abstract
Insulin resistance (IR) is a central mechanism of diabetes mellitus type 2 (DM) evolution and metabolic syndrome on the whole. It is closely related to such cardiovascular risk factors as hypertension and dyslipidemia. This study investigated the role of adipokine – resistin as marker of vascular lesions on the background of insulin resistance, and tumor necrosis factor-α - as an early marker of insulin resistance in patients with essential hypertension (H) and insulin resistance in various stages of progression. 134 patients with hypertension, insulin resistance and diabetes mellitus were included and were divided into 3 groups: 1 group- patients with hypertension, 2 group - patients with H and IR (n = 46), group 3 - patients with H and DM (n = 48). Control group - 20 healthy volunteers matched for age and sex with a patients. Fasting plasma levels of insulin, glucose, blood lipids, tumor necrosis factor-α, resistin were determined. For the IR determination the HOMA–IR index was used. In this study a close relationship between insulin resistance and hypertension confirms the important role of adipokines in the development and progression of hypertension. The leading role of the adipocyte-derived cytokines and proinflammatory condition on the the background of endothelial dysfunction in the pathogenesis of obesity and hypertension in combination with insulin resistance was determined.
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