冠状動脈疾患に関する研究 (第2報) : 冠硬化症における血清コレステロールおよびリポ蛋白の意義について

Abstract

Recent observations in the field of lipid chemistry have suggested that disturbances in serum lipid metabolism may be responsible for the progression of the human atherosclerosis.The disturbances are (1) an elevation of the total serum cholesterol and (2) an increase in the concentration of certain serum lipoproteins, particularly those in beta-fraction.Thus, in order to establish a relationship between disturbances of the serum lipids and the coronary atherosclerosis, the determinations of the serum cholesterol and lipoprotein index (beta-fraction/alpha-fraction) were made on 329 officers and clerks.Then, 75 cases were reexamined one year after the initial examination and the reliability of blood lipid levels as a precaution for incidence of CAD was evaluated.1) In both the normal and the abnormal groups, most of the cases with high relative weight had high levels of total serum cholesterol and/or lipoprotein index. Higher average levels of total serum cholesterol and lipoprotein index in abnormal group than in normal may be caused by the fact that former group includes many cases with high relative weight.2) The group with aggravation in one year period had larger number of cases with high levels of total cholesterol and/or lipoprotein index at the first examination as compared with the group without aggravation.3) It was found that high levels of total serum cholesterol and/or lipoprotein index were associated not only with coronary atherosclerosis, but with overweight and with attacks of myocardial infarction or angina pectoris.4) For the evaluation of total serum cholesterol or lipoprotein index as an index of coronary atherosclerosis, relative weight and/or incidence of coronary heart disease must be considered.