Ендотоксикоз і запалення як предиктори поглиблення функціональної недостатності підшлункової залози при хронічному панкреатиті у поєднанні із цукровим діабетом 2 типу

Abstract

According to scientists, a significant role in the progression of chronic pancreatitis (CP) and diabetes mellitus (DM), as well as in the occurrence of complications of these diseases, is played by inflammation and endogenous intoxication by the products of protein breakdown as a result of the inflammatory process, fibrosis, and degradation of connective tissue in the patient’s body, in particular, and in the pancreas. The aim is to analyze the state of parameters of inflammation, endotoxicosis, and their influence on the functional capacity of the pancreas in the comorbid course of chronic pancreatitis and type 2 diabetes mellitus (DM2). Materials and methods. 112 patients with CP in the phase of mild therapeutic exacerbation in combination with DM2 in the stage of subcompensation were examined. The results. Moderate and moderate inverse correlations were established between CRP and fecal α-elastase in patients with CP and comorbidity of CP and DM2 (respectively r=-0.423 and r=-0.565, p<0,05). An increase in the strength of reliable direct moderate correlations between the levels of HbA1c and CRP in patients with CP in combination with DM2 compared to those with isolated CP (respectively r=0.313 and r=0.410, p<0,05) was proved. Conclusions: We proved a reliable influence of the index of endogenous intoxication on the level of pancreatic functional insufficiency according to the content of fecal α-elastase, which was more significant in the combined course of CP and DM2 compared to that in isolated CP. An increase in the strength of reliable direct, moderate, and moderate correlations between HbA1c levels and the index of endogenous intoxication in patients with isolated CP and CP in combination with DM2 has been proven.