Abstract
The antitumor activities of cyclophosphamide (CPA) on Ehrlich solid tumor in mice were examined alone and in combination with immunopotentiators. Killed Mycobacterium butyricum (MB), OK-432 (Picibanil) and lipopolysaccharide (E. coli, LPS) prolonged the pentobarbital-induced sleeping time of mice with dose-dependence. MB and LPS markedly inhibited the antitumor activity of CPA. In MB-or LPS-treated mice, the analgesic action of aminopyrine was increased and the action of codeine phosphate was decreased. These immunopotentiators may change the activity of combined drugs by inhibition of the hepatic microsomal drug-metabolizing system.
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