Декарбоксилирование 2'-дикарбокси-5-(метил-5'индолил-3')-индолил-3-уксусной кислоты с использованием одновалентной меди

Abstract

In this article a decarboxylation method based on the use of quinoline with a copper salt is discussed. Decarboxylation is the elimination of CO2 from the carboxylic group of carboxylic acids or the carboxylate group of their salts. The process is used to produce a large number of organic compounds, such classes as alkanes, alkenes, alcohols, ketones, ethers and esters. Decarboxylation plays an important role in the metabolism of living organisms, namely in the decarboxylation of amino acids. From this we can conclude that the process is important to study. Decarboxylation proceeds in different ways. The most common methods of decarboxylation includes heating in various conditions. For example, such as heating in the presence of acids and alkalis, under severe conditions with quinoline, thermal oxidation in the presence of transition metal salts, Kolbe reaction. In the procces of the CO2 removal group in relation to amino acids there are several types: α-decarboxylation, decarboxylation, associated with the trans-amination reaction and the condensation reaction of molecules. In the synthesis of substituted auxin 2'-dicarboxy-5-(methyl-5'indolyl-3')-indolyl-3-acetic acid, the yield of the product was not high. The usual heating in the presence of alkali output was less than 5%, and in this work it was decided to use other methods of decarboxylation to increase the yield of the product. The aim of the work is to improve the method of decarboxylation of carboxyindolyl substrates for increasing product yield and to compare with the result obtained by ordinary heating of this substances in the presence of alkali. At the end of the work summed up. Found the optimal conditions for the process of decarboxylation of investigated substrates. Optimal conditions chosen based on product yield. To confirm the chemical structures of the substances, 1H NMR, IR spectroscopy, and elemental analysis were used.