Влияние комбинированного орального контрацептива, содержащего 17β-эстрадиол, на состояние вагинальной среды у женщин

Abstract

Objective . To study the effect of a combined oral contraceptive (COC) containing 2.5 mg of nomegestrol acetate (NOMAC) and 1.5 mg of 17β-estradiol (E 2) (NOMAC-E 2) on microbiocenosis and status of the vaginal environment in women of reproductive age. Material and methods. The study involved 52 generally healthy women in need of contraception aged 18 to 49 years. The average age was 35.1 (3.9) years. Before and after 6 months of COC use the microbiocenosis, vaginal moisture and acidity (pH) have been determined, a correlation with the level of sex hormones in the blood has been performed. Results . After 6 months of using COC containing NOMAC-E 2 normal flora with a predominance of lactobacilli was determined in 50 (96.2 %) women. There was a significant increase in vaginal moisture, tendency to increase the acidity of vaginal environment has been obtained. The use of pairwise correlation method did not reveal any statistically significant relationships between the changes in pH values, vaginal moisture content and the level of sex hormones and SHBG level. Conclusion . The use of COC containing NOMAC-E 2 for 6 months does not have adversely effect on microbiocenosis and state of the vaginal environment in women of reproductive age.