ПОРІВНЯЛЬНИЙ АНАЛІЗ ТАБЛЕТОК АДЕМЕТІОНІН 1,4-БУТАНДИСУЛЬФОНАТУ ТА РЕФЕРЕНТНОГО ПРЕПАРАТУ МЕТОДОМ ІНФРАЧЕРВОНОЇ СПЕКТРОСКОПІЇ

Abstract

Introduction Infrared analysis – is a universal physial method that is applied in the research of structural features of different organic and inorganic compounds. Its peculiarity is possibility to carry out the research without previous sample processing that is very important during the work with moisture-retentive chemicals. During the molecule is irradiated by infrared light only those quanta are absorbed frequency of which agree with frequency of valence, deformational and vibrational motion of the molecules [2,3]. Investigation methods Were studied: lot 20515 (pattern №1 that was got under the environmental humidity of 15%), lot 10314 (pattern №2, environmental humidity 20%), lot 10513 (pattern №3, environmental humidity 30%) and lot 11113 (pattern №4, environmental humidity 40%). Received pills were being investigated with the help of absorption infrared spectroscopy (AIR spectroscopy) in the intermediate infrared band (4000-400 cm -1 ). During the researches apparatus Thermo Nicolet IS50 with ATR module. Results and discussions This way, in accordance with the results of our researches the mechanisms of transformation of ademetionine structure under the influence of water or –OH groups. Received data confirm that optimized climatic conditions for the production of pills on the basis of the substance ademetionine 1,4 butandisulfonate is environmental humidity not higher than 20%, and the temperature 20 °С. Conclusions Comparative analysis of ademetionine 1,4 butandisulfonate pills of different series and reference listed drug «Heptral» was carried out with the help of infrared spectroscopy. It is shown that infrared absorption spectroscopy as operational method of the analysis allows to study the influence of the humidity on structural-informative qualities of the substance ademetionine 1,4 butandisulfonate in developing preparations. It’s experimentally determined and confirmed that optimized climatic parameters of getting pills, environmental humidity not higher than 20% and the temperature 20°С.