Abstract
In order to make comparative examinations of the effect of substituting the alkyl in 4-position with other groups on the antibacterial action, dyes having 2, 5-dimethyl-thiazole ring possessing a benzyl or phenyl group in 4-position were synthesized. dl-Phenylalanine and 2-phenylglycine were derived to N-(α-acetylphenethyl)acetamide and N-(α-acetylbenzyl)acetamide by the Dakin-West reaction and submitted to substitution-cyclization with phosphorus pentasulfide to form 2, 5-dimethyl-4-benzyl- and 2, 5-dimethyl-4-phenylthiazoles. Using their quaternary salts as the starting material, 12 kinds of styryl-type dyes were synthesized by condensation with aromatic aldehydes and 19 kinds of aminovinyl-type dyes by fusion and condensation with formamidines. The dyes thereby synthesized were submitted to antibacterial tests with four kinds of typhoid bacilli and staphylococci.
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