Abstract
p-Substituted β-haloethyl ketone derivatives of benzene, acetaminobenzene, and formylaminomethylbenzene were prepared and their bacteriostatic activity in vitro was tested. These compounds were found as effective as acrylophenone compounds against E. coli, Staph. aureus, and Myco. tuberculosis.The compounds convert easily to the corresponding acrylophenone in weak alkaline medium under liberation of hydrogen halide. The mode of action of the compounds is assumed to consist of the primary conversion of β-haloethyl ketones to the vinyl ketone form, and reaction of the latter with a certain sulfhydryl group, which is significant to metabolism of organisms.
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