Abstract
Sixteen kinds of compounds including 2-(2, 4-dihydroxy-6-methylbenzylidenehydr-azono)-4-thiazolidone and 2-(2, 4-dihydroxy-3, 6-dimethylbenzylidenehydrazono)-4-thiaz-olidone were synthesized by reacting thiosemicarbazones with ethyl chloroacetate and sodium acetate in ethanol. A total of 27 kinds of compounds including these and other known compounds were submitted to antibacterial tests against human type tubercle bacilli H37Rv and following conclusions were drawn:1) As the ring bonded to the =N-N=CH- in 2-position of 2-arylidenehydrazono-4-thiazolidone, benzene has the strongest antibacterial activity, as was stated by Taniyama and others, and the presence of one hydroxyl in the ortho-position of such benzene ring showed the strongest activity.2) Alkoxycarbonyl group increased antibacterial action.3) Introduction of a chlorine generally tended to increase the antibacterial action. In 2-(2, 4-dihydroxy-5-alkylbenzylidenehydrazono)-4-thiazolidones, the antibacterial activity was in inverse proportion to the length of the alkyl chain.
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