ラネーニッケル合金とアルカリ水溶液による含窒素化合物の還元 その1

Abstract

Synthesis of amines was attempted by the reduction of nitrogenous compounds, such as oximes, by the utilization of hydrogen which is generated when Raney nickel is developed in alkaline solution. The oxime and aqueous alkali were placed in a flask provided with fractionation column, dropping funnel, and cooler for steam distillation. Raney nickel was added to this mixture in one lot, allowed to react in the cold, and water added from the funnel when the reaction became mild. Steam distillation of this mixture gave pure amine in a short time. Reduction of nitriles was also successful by this method but details of this will be reported after further examination. The compounds obtained from corresponding oximes were as follows: Benzylamine, 3, 4-dimethoxybenzylamine, 3, 4-methylenedioxybenzylamine, α-phenethylamine, β-amino-α, γ-diphenylpropane, benzhydrylamine, and cyclohexylamine.