Abstract
Infantile diarrhoea with white stool occurs every winter from November to March in Sendai. The virus isolation was attempted from 26 cases of this diseases occured from November 1965 to February 1966. Employing human embryonic kidney fibroblasts, cytomegalovirus (CMV) was isolated from the throat swabs of 6 cases of 17 (35.3%). Then CF antibody against the isolated strain of CMV in paired sera obtained from the patients was titrated. However, significant rise of CF antibody was demonstrated only in 2 cases of 19 and the CF antibody was detected even in the acute sera obtained from 10 cases of 19. The CF antibody against the same virus in sera obtained from the healthy infants was also titrated in the comparative manner. The CF antibody was found in 46.4% of them on summer 1965, in 35.3% on autumn before the occurrence of the disease, in 31.5% on winter during the epidemic of the disease and 47.4% on next spring after the epidemic, while demonstrated in 61.3% of the patients.Thus CMV may be or may not be the etiological agent of this disease, although the seroepidemiological results that CMV seemed to be spread in the winter during the epidemic of the disease, taken together the high ratio of CMV isolation from the patients, suggested the posibility that CMV may be the cause of this disease.
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