Abstract
Pharmacological activity of various fractions of the aqueous extract of a Chinese drug, “Shin-i” was examined by the Magnus method, with that of “Shin-i” on the rectus abdominis of a frog as the index, comparing drugs prepared in Japan and in China. In general, there was no pharmacological difference between these two kinds of preparations in any of the fractions. The only crystalline component obtained from the phenolic base of both products was an alkaloid of m.p. 208°, with empirical formula of C17H19O3N, which was found to have a curare-like action by experiment with nerve muscle preparation. Aqueous extract, corresponding to the decoction in Oriental medicine, showed a marked acetylcholine-like action and it was proved by comparative examination of various methods of extraction that the predominant active component in this fraction cannot be obtained by the usual method of alkaloid extraction in order to find the cause of such action. It was also revealed that the pharmacological activity of the aqueous extract was the cumulative result of additive and cancellative action of each fraction.
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