Abstract
Noradrenaline modulates ovarian steroidogenesis, stimulates ovulation, and probably promotes follicular development in the ovary. It has been suggested that these effects of noradrenaline are mediated by α- and/or β-adrenergic receptors (ARs) in the ovary. The purpose of the present study was to examine whether α 1-AR is present in the rat ovary. In Western blotting, antibody against α 1-ARs recognized a major protein in the ovary of adult (10-week-old) rats with a molecular weight of 80 kDa, which is similar to that of the α 1B-AR subtype. Immunohistochemistry using this antibody showed that α 1-AR was detected at various sites in the ovary, including large antral follicle, germinal epithelium at the circumference of large antral follicle, corpus luteum, and interstitial tissue. These results confirm that the ovary contains α 1-AR (probably α 1B-subtype), and suggest that this receptor mediates some of the activities of noradrenaline in the regulation of ovarian functions. Furthermore, we found that α 1-AR is present in oocyte of large antral follicle, suggesting that noradrenaline acts on oocyte via this receptor.
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