Abstract
A mixture of lactose powders and small-sized lactose granules (32-80 mesh) was shaken in a cylindrical metal vessel and the degree of mixing was examined. The miscibility of the micronized powder with small-sized granules was good. The micronized powder contained as much as 27.8% small particles with diameters less than 10 μm, and it is thought that its cohesive and adhesive property brought about such an improvement in the degree of mixing. The eosine-coated powder exhibited a low degree of mixing, possibly because the adhesive force of these powder particles to the surface of lactose granules, as measured by a modified centrifugal method, was small (0.021 dyn), and cohesion among the particles was large (0.214 dyn). The eosine-coated powder and the powder containing 1% talc were rather free-flowing. However, no improvement on the degree of mixing was obtained by the increase in flowability of the powders.
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