Abstract
The article presents the description of the changes in the concentrations of pro‐inflammatory
 cytokines and soluble forms of selectins and immunoglobulin superfamily adhesion molecules in patients
 with chronic generalized slight periodontitis. Serum concentrations of interleukin‐1‐β, tumor necrosis factor‐
 α, soluble forms of P‐ and E‐selectins, intercellular adhesion molecule (ICAM‐1), vascular adhesion molecules
 (VCAM‐1) and platelet‐endothelial adhesion molecules (PECAM‐1) in healthy subjects and patients
 with slight periodontitis before and after treatment were assessed. It was found that the serum concentration
 of sICAM‐1, sVCAM‐1, sP‐, sE‐ selektins and pro‐inflammatory cytokines are increased in patients with
 chronic generalized periodontitis. The increase of serum concentration of soluble forms of selectins is expressed
 more significantly than sICAM‐1 and sVCAM‐1. There are no statistically significant changes of serum
 sPECAM‐1 in the examined group of patients in comparison with control. Complex therapy, including
 etiological and pathogenetic treatment, is completely normalized the concentration of pro‐inflammatory cytokines,
 and soluble forms of studied endothelial adhesion molecules in patients with chronic generalized
 slight periodontitis. All the studied parameters in patients with chronic generalized slight periodontitis after
 treatment are in the range of the control group variability.
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