Abstract
In this work, functional aspirin (ASP) incorporated biodegradable materials for transdermal drug delivery system were prepared using mungbean starch (MS), polyvinyl alcohol (PVA), sodium benzoate (S), xylitol (XL), and melanin (MEL). In addition, physical properties, photothermal conversion effect, and ASP release properties for prepared functional ASP incorporated biodegradable materials were investigated. Prepared biodegradable materials was analyzed using a Field emission scanning electron microscope (FE-SEM) and Fourier transform infrared spectrophotometry (FT-IR). Phototheramal conversion effect and ASP release properties were evaluated with NIR laser (1.5W/㎠) irradiation time. Results of photothermal conversion effect with NIR laser irradiation indicated that the temperature increase of MEL added biodegradable materials were about 3.5 times higher than MEL non-added biodegradable materials. ASP release ratio(%) of MEL added biodegradable materials with NIR laser irradiation were about 1.5 times faster than MEL non-added biodegradable materials. From the results, prepated functional biodegradable materials are expected to be applied as biomedical material for acute antipyretic, painkiller and cardiovascular disease treatment.
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