СИНТЕЗ И ИССЛЕДОВАНИЕ ФИЗИКО-ХИМИЧЕСКИХ СВОЙСТВ НАНОРАЗМЕРНОГО ГИДРОКСИАПАТИТА, ДОПИРОВАННОГО КАРБОНАТ- И СИЛИКАТ-АНИОНАМИ

Abstract

Hydroxyapatite [Ca10(PO4)6(OH)2, HAp] is similar in chemical composition to bone tissue and widely used in clinical practice as a bone graft substitute. However, unmodified HAp has a low rate of resorption and a weak stimulating effect on the growth of new bone tissue. The introduction of carbonate ions into the structure of the HAp significantly affects the mineralization process and increases the rate of osseointegration. Silicon anions (up to 5%) also play an important and positive role, especially in the initial stages of bone matrix formation. In this regard, doping of synthetic hydroxyapatites with carbonate and silicate anions seems promising. This paper presents the results of the physico-chemical analysis of hydroxyapatite (HAp) samples doped with carbonate and silicate anions (CНAp, Si-HAp) synthesized by chemical precipitation in aqueous alkaline solutions. The structure and properties of the obtained samples are characterized using X-ray powder diffraction (XRD, transmission electron microscopy (TEM), scanning electron microscopy (SEM) and infrared spectrometry(IR). It is established that during the precipitation of the solid phase of HAp, a partial of phosphate ions is replaced by carbonate and/or silicate anions. The results show that the synthesized materials have nanoscale-crystallites with needle-shaped (HAp) and/or spherical forms (CНAp, Si-HAp) (12-85.5 nm) and are single-phase. The intrusion of carbonate and silicate anions into the structure of HAp significantly affects their morphology and particle size. This allows to consider CHAp and Si-HAp samples as promising biomaterials for orthopedic and dental prosthetics.