Abstract
The research focuses on peculiarities of lipid peroxidation processes in women with reproductive disorders associated with chronic endometritis. The control group included 50 women of reproductive age with chronic endometritis, whose average age was 29.7 ± 4.7years. The comparison group consisted of 50 women of the same age with reproductive disorders without chronic endometritis, who had signed informed consent. We followed ethical principles and requirements of the Declaration of Helsinki of the World Medical Association. Insufficient activity of peroxidation processes which is characterized by a decrease in the concentration of primary ((DC - 1.11 ± 0.05 for the control group and 1.43 ± 0.08 for the comparison (p < 0.05)) peroxidation products, an increase in concentration of intermediate ((KD) - 0.53 ± 0.03 and 0.36 ± 0.03 respectively (r < 0,001)) peroxidation products and increased content of double bond substrates: 1.82 ± 0.07 and 1.11 ± 0.07 respectively (r < 0,001) compared to the patients with reproductive disorders without chronic inflammation of the endometrium which therefore indicates the presence of oxidative stress in women with reproductive disorders and chronic endometritis. The results of discriminant analysis showed that the diene conjugates are the most informative indicators of the lipid peroxidation system, indicating the differences between the group of patients with chronic endometritis and the group of patients without inflammation.
Highlights
The research focuses on peculiarities of lipid peroxidation processes in women with reproductive disorders associated with chronic endometritis
The comparison group consisted of 50 women of the same age with reproductive disorders without chronic endometritis, who had signed informed consent
Insufficient activity of peroxidation processes which is characterized by a decrease in the concentration of primary ((DС – 1.11 ± 0.05 for the control group and 1.43 ± 0.08 for the comparison (p ≤ 0.05)) peroxidation products, an increase in concentration of intermediate ((KD) – 0.53 ± 0.03 and 0.36 ± 0.03 respectively (r ≤ 0,001)) peroxidation products and increased content of double bond substrates: 1.82 ± 0.07 and 1.11 ± 0.07 respectively (r ≤ 0,001) compared to the patients with reproductive disorders without chronic inflammation of the endometrium which indicates the presence of oxidative stress in women with reproductive disorders and chronic endometritis
Summary
Нами было обследовано 50 женщин репродуктивного возраста с хроническим эндометритом, средний возраст которых составил 29,7 ± 4,7 года. В качестве материала для определения показателей ПОЛ использовали сыворотку и плазму крови, гемолизат из эритроцитов. Определение содержания ТБК-активных продуктов проводили по В.Б. Значимость межгрупповых различий показателей устанавливалась с двусторонним Z-критерием. Для количественных переменных в группах сравнения определяли среднюю арифметическую величину (М), стандартное отклонение (σ), медиану (Ме), стандартные ошибки средних, 95%-е доверительные интервалы. Анализ межгрупповых различий для независимых выборок по каждому из нормально распределенных количественных признаков проводили с помощью параметрических критериев Стьюдента (t-критерий) и Фишера (F-test), для ненормально распределенных – с помощью непараметрических критериев Манна – Уитни (U-test), Колмогорова – Смирнова (K-S), Вальда – Вольфовица (WW). Внутригрупповые взаимосвязи количественных признаков определяли корреляционным анализом Пирсона (для нормально распределенных величин) и непараметрическим методом Спирмена. Многофакторный дискриминантный анализ позволил выявить значимость наиболее информативных показателей и оценить их эффективность для классификации наблюдений.
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