Abstract
The polarographic technique was used to examine the oxygen permeability of the round window membrane in 14 cats.Under general anesthesia, a small hole was drilled in the first turn of the bony wall of the cochlea. An oxygen sensing microelectrode with a tip diameter less than 1μm was inserted through the hole into the scala tympani. Dynamic changes in perilymphatic oxygen tension were measured by applying compressed air, pure oxygen, carbogen (95% O2+5% CO2), and nitrogen gas to the round window membrane via the middle ear cavity.1) The gasses easily pass through the round window membrane into the perilymphatic space.2) The level of the perilymphatic oxygen tension is in part under the control of the oxygen concentration in the middle ear cavity.3) A gradient in the perilymphatic oxygen tension is present, increasing with the distance from the round window membrane.
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