ОСОБЕННОСТИ МОРФОЛОГИИ И ИММУНОФЕНОТИПА САРКОМАТОИДНОЙ ПОЧЕЧНО-КЛЕТОЧНОЙ КАРЦИНОМЫ

Abstract

Sarcomatoid renal cell carcinoma is a relatively rare tumor and accounts for about 5% of allrenal cell carcinomas. The results of multivariate prognostic modeling show that the presence of sarcomatoid differentiation in renal cell carcinoma is an unfavorable predictor of the clinical course and underlying diseases. Objective - а comparative analysis of the expression of a number of proteins in carcinomatous and sarcomatoid components in various histological variants of sarcomatoid renal cell carcinoma and an assessment of their diagnostic significance. Surgical specimens from 49 patients diagnosed with renal neoplasms were investigated. Paraffin sections were immunohistochemically examined using the standard protocol. Based on the morphological analysis and IHC studies, out of 49 neoplasms in 24 (49%) cases revealed morphoimmunohistochemical signs of clear cell renal cell carcinoma, in 9 (18%) neoplasms chromophobe renal cell carcinoma, in 8 (16%) samples -papillary renal cell carcinoma, in 1 (2%) collecting duct carcinoma and in 2 (4%) cases, unclassified renal cell carcinoma. In 4 (8%) samples tumor cells did not express specific markers of renal cell carcinoma and in additional immunophenotyping 2 (4%) cases of leiomyosarcoma and solitary fibrous tumor were diagnosed, respectively, and in 1 (2%) case – monophasic synovial sarcoma. There is a relationship between the number of sarcomatoid cells and the tumor stage in sarcomatoid renal cell carcinomas. It was found that the number of sarcomatoid cells in the stages of pT3-pT4 (n=28; 64%), in the majority of cases (n=27; 96%), was more than 50% of the entire tumor population.