Abstract
This paper discusses connective tissue disorders (CTD), in particular, undifferentiated connective tissue disease (UCTD) whose importance is accounted for by a high prevalence of this condition. Generalized connective tissue damage that involves reproductive system significantly affects the course of pregnancy and delivery. The complications of pregnancy, delivery, and postpartum period in women with UCTD which often require surgical procedures (i.e., amniotomy, episiotomy, perineotomy, C-section etc.) are described. The paper highlights the role of magnesium which is of crucial importance for the complex biosynthesis of extracellular matrix during connective tissue formation and fibroblast morphological functional status. The tests for connective tissue metabolic disorders (blood oxyproline and fibronectin, urine pyrilinks-D and glycosaminoglycans etc.) are addressed. Considering the lack of the reliable diagnostic (biochemical and genetic) criteria for UCTD, the authors advocate the need for a complex examination using anamnestic data and the results of clinical, instrumental, and laboratory tests.KEYWORDS: connective tissue disorders, hemostasis, complications of pregnancy and delivery, magnesium deficiency, endothelial dysfunction, markers of collagen degradation, genital prolapse.FOR CITATION: Il’ina I.Yu., Chikisheva A.A. Course of the pregnancy in women with connective tissue disorders. Russian Journal of Woman and Child Health. 2020;3(3):182–188. DOI: 10.32364/2618-8430-2020-3-3-182-188
Highlights
This paper discusses connective tissue disorders (CTD), in particular, undifferentiated connective tissue disease (UCTD) whose importance is accounted for by a high prevalence of this condition
Generalized connective tissue damage that involves reproductive system significantly affects the course of pregnancy and delivery
The paper highlights the role of magnesium which is of crucial importance for the complex biosynthesis
Summary
РЕЗЮМЕ Статья посвящена проблемам, связанным с дисплазией соединительной ткани (ДСТ), преимущественно недифференцированных форм заболевания (нДСТ). Генерализованный характер повреждения соединительной ткани с вовлечением в патологический процесс репродуктивной системы существенно сказывается на течении беременности и родов. Которому принадлежит одна из определяющих ролей в сложном биосинтезе экстрацеллюлярного матрикса при формировании соединительной ткани и в морфофункциональном состоянии фибробластов. Ввиду отсутствия достоверных диагностических (биохимических и генетических) критериев нДСТ особое внимание обращено на необходимость комплексного подхода к оценке состояния пациенток с использованием данных анамнеза, результатов клинико-инструментального и лабораторного обследования. КЛЮЧЕВЫЕ СЛОВА: дисплазия соединительной ткани, гемостаз, осложнения беременности и родов, дефицит магния, дисфункция эндотелия, маркеры распада коллагена, пролапс гениталий. Особенности течения беременности у пациенток с дисплазией соединительной ткани.
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