慢性副鼻こう炎鼻汁の研究 ＩＩ セアプローゼＳの影響

Abstract

The purpose of this study was to evaluate the effect of Seaprose-S (SAP), a representative proteolytic enzyme, on the nasal secretion from patients with chronic sinusitis. Retained nasal secretion in the nasal cavity was carefully aspirated from 17 patients who were selected on the basis of rhinoscopy and radiology. The nasal secretions obtained were diluted 8-fold with distilled water. Relative viscosity was measured by a method of the falling rate of a metal ball. Dry weight, amounts of total protein, albumin and DNA were determined before and every week during the period of drug administration. SAP was given in a dose of 45mg/day orally for more than four weeks.At week 0, the mean relative viscosity, dry weight, amounts of total protein, albumin and DNA were 2.83±2.06, 59.40mg/g±48.18, 38.83mg/g±14.49, 2.20mg/ml±1.46 and 31.15mcg/g±18.80, respectively. Significant correlations were noted between relative viscosity versus dry weight, and relative viscosity versus amount of total protein. At week four, the variables were 2.22±1.94, 52.40mg/g±40.91, 40.53mg/g±10.18, 2.82mg/ml±0.91 and 32.24mcg/g±19.78. At week five, they were 2.18±1.35, 59.24mg/g±48.37, 34.56mg/g±12.74, 3.04mg/ml±2.10 and 43.64mcg/g±40.85, respectively.The large variability among the patients precluded the quantitative changes in these variables by the SAP therapy. However, relative viscosity significantly decreased at weeks four and five. There were no significant differences for dry weight, and amounts of total protein, albumin and DNA between week 0 and weeks four and five.