粘液線毛輸送系と気道クリアランス 電気光学的方法による線毛運動の観察

Abstract

The function and morphology of the nasal mucociliary system in a normal and some pathological states was studied with special reference to the ciliary activity and morphology of nasal epithelial cells.The following results have been derived from the present investigation.1. The value of the nasal ciliary activity of the healthy human and animal was about 700-900 beats per minute at 30°C in the physiological saline solution.2. The first appearance of the ciliary activity at the nose of fetal rabbits was on the 26th day of the fetal stage. The nasal ciliary activity in fetal rabbits had the quantitative maturity but did not have the qualitive maturity indicated by the disorder in its direction.3. The ciliary activity was not affected by a single antigen-antibody interaction. On the other hand, the ciliary activity was declined by the frequent reccurence of antigen-antibody interaction.4. The ciliary activity of the nasal mucosa derived from rabbits was declined in association with the irradiation dose. In addition, the functional and morphological damages of the nasal epithelium after the irradiation were not easily recovered.5. The exposure to tetrahydrofuran affected the nasal ciliary activity of rabbits and the recovery of the nasal ciliary activity was observed in a few hours when the concentration of tetrahydrofuran was rather low.6. The ciliary activity at the nasal epithelium was declined by 4 weeks exposure to SO2 of 20 ppm. The complete recovery of the nasal ciliary activity was not observed 2 weeks after the stoppage of the exposure to SO2.7. The functional and morphological damages of the nasal mucosa with intact basal cells by the mechanical injury were recovered in about 5 days. On the other hand, it took about 6 weeks to recover from the damages when the basal cells and basement membrane were affected.