Каротидный атеросклероз и суточный профиль артериального давления у коренного и пришлого населения Крайнего Севера

Abstract

Objectives: To study the patterns of atherosclerotic lesions in brachiocephalic arteries, 24-hour blood pressure monitoring data, and heart rate variability in patients with arterial hypertension (AH) and coronary artery disease (CAD) among indigenous and alien populations of Yamalo-Nenets Autonomous District. A total of 100 patients aged 21-55 years (mean age of 52.3±0.4 years) with AH and CAD living in the Far North were examined. All patients were divided into two groups of 50 people each: group I included native population, group II included alien population. The patients underwent outpatient duplex scanning of brachiocephalic arteries and 24-hour blood pressure monitoring; heart rate variability and lipid profile were evaluated. Groups matched by age and gender. Duplex scanning of brachiocephalic arteries detected thickening of the intima-media complex of the common carotid artery in all patients: the highest level was observed in native inhabitants (p<0.001), the tendency to more frequent atherosclerotic stenosis of the left internal carotid artery (p=0.058) was found in natives compared with alien population. The lowest atherogenicity of lipid profile in native inhabitants was mediated by higher HDL level compared with alien population. Atherogenicity of lipid profile in alien population was characterized by a significantly higher level of triglycerides (p=0.035) and VLDL (p=0.021). Heart rate variability analysis revealed pronounced stress of the regulatory systems in most patients from both groups. The results of 24-hour blood pressure monitoring did not show significant differences.