Abstract
Objective: The aim of this study is to identify the altered functional connectivities of the salience network during resting state among individual with alcohol use disorder using functional magnetic resonance imaging.BRBRBackground: Individuals with Alcohol Use Disorder (AUD) has shown significant attention and attraction to alcohol-related stimuli. The previous studies demonstrated the neuropsychological, physiological responses elicited by alcohol-related cue. These researches suggested the altered functional connectivities between brain areas related to incentive salience among AUD patients, but not yet fully explored the functional connectivities in salience network during resting-state among AUD patients in the literatures.BRBRMethod: In this study, functional magnetic resonance imaging data were acquired for 22 AUD patients and 22 healthy controls with similar demographic characteristics. The functional connectivities between the regions in salience network was chosen as the region of interest (ROI), and the ROI to ROI analysis with time series signals was conducted. After that two-sample t test was performed.BRBRResults: In the results, AUD patients exhibited increased functional connectivities in the right anterior insula - left supramarginal gyrus, the right supramarginal gyrus - left rostral prefrontal cortex, right supramarginal gyrus - right rostral prefrontal cortex, and right supramarginal gyrus - left supramarginal gyrus compared to healthy controls. The strengths of functional connectivity in these areas were linked to the severity of AUD measured by Alcohol Use Disorder Identification Test (AUDIT).BRBRConclusion: The results of the study suggest that abnormal incentive salience toward alcohol-related stimuli might be associated with the aberrant functional connectivities in salience network.BRBRApplication: The aberrant functional connectivities in salience network might apply for discrimination of AUD, and determination the severity of AUD as neuroimaging markers.
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