Abstract
Novel after-loading interstitial therapy was performed in a canine transmissible sarcoma (CTS) model, utilizing photofrinII and an excimer dye laser. First, photofrinII was injected intravenously at a dose of 5mg/kg, the 48h later, laser-proof plastic tubing was implanted in the CTS and optical fiber was inserted into the tubing, followed by photoradiation of the tumor from the inside. The mean diameter of tumor necrosis rapidly increased in parallel with increase in total irradiation energy below 240J/cm, the mean diameter of tumor necrosis was 20.7mm after energy of 120J/cm, and 24.5mm at 240J/cm. Beyond 240J/cm, the diameter gradually increased to 26mm at 960J/cm. As a side effect, cutaneous tissue showed a deep open ulcer at 240J/cm, a shallow ulcer 120J/cm. The thermal effect of laser light is considered negligible below 480J/cm. In addition, 3 hours later after an intravenous administration of BPD-MA verteporfin at a concentration of 2mg/kg, PDT was performed in CTS at conditions of 0.32watt with novel afterloading interstitial PDT using excimer dye laser. At a dose of 150J/cm, the diameter of tumor necrosis was estimated to be 35mm. The problems and future prospects of this interstitial PDT was discussed.
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