Изменения цитокинового профиля в зависимости от тяжести эндогенной интоксикации при механической желтухе

Abstract

Aim. Study of the reaction of the cytokine pofil to the severity of the course of endogenous intoxication in patients with obstructive jaundice.Material and methods. The study involved 84 patients with obstructive jaundice (MJ) caused by malignant tumors of the biliopancreatoduodenal zone (BPDZ). There were 55 men (65.5%), women - 29 (34.5%). The average age of the patients was 59.1 ± 2.3 years. The severity of endogenous intoxication and the cytokine profile of patients with breast cancer were assessed by determining the concentration of medium molecular peptides (MMP) and proinflammatory cytokines TNF-α and IL-6 in blood plasma and bile.Conclusion. In patients with breast cancer of tumor genesis, there is a multiple increase in the concentration of proinflammatory cytokines in blood serum and bile. There is also a manifold increase in apoptosis indices of blood lymphocytes and the content of MMP. Adequate and timely decompression of the biliary tract in breast cancer ensures the elimination of factors that cause endogenous intoxication and an increase in the inflammatory process, which makes it possible to prepare the patient for the second stage of radical surgical treatment after of the aplication of a percutaneous-transhepatic cholangiostomy.