Abstract
It is well known that human T-cell leukemia virus type 1 (HTLV-1) infection is contributed to deficient immunity.Some association between HTLV-1 infection and hepatitis virus infection were investigated, particularly the effect of HTLV-1 infection on the acquisition of hepatitis B and C virus carrier state, and on liver function in hepatitis virus carriers.The subjects consisted of 945 HTLV-1 positive donors aged 16-64 (mean±S. D.=37.4±11) and 2, 000 negative controls aged 16-64 (mean±S. D.=30.4±10).The prevarence of hepatitis B surface antigen in HTLV-1 positive donors and negative controls were 1.9% and 1.6%, respectively. However, there was no statistically significant difference. On the other hand, the prevalence of antibody to hepatitis C virus in HTLV-1 positive groups was 2.5% and significantly higher than in negative controls being 0.4%. Frequency of donors with high value of GPT was not different between HTLV-1 positive group and negative.In conclusion, HTLV-1 infection may not affect on the acquisition of HBV carrier state and liver function. However, an association between HTLV-1 and HCV infection was suggested.
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