Abstract
The article presents data on the bacteriological control of the effectiveness of various methods of draining fresh accidental wounds with a wide area of damage in different species of animals: semipermeable membranes and tubular perforated drains. Semi-permeable cellulose membranes (experimental group) were inserted into the wound of animals with absolute indications for drainage at the final stage of surgical treatment.These membranes were filled with a hyperosmolar dialysis solution containing antibacterial preparations. The comparison group used the introduction of antiseptics through perforated tubular drains. In order to study the quantitative and qualitative composition of microflora in the wound process, bacteriological studies of swabbings from the wound surface and from the wound canal were performed on 1-3-7-9 days. As the result, it was established that the degree of tissue contamination depends on the duration of surgical debridement ,type and conditions of animals. The study of quantitative composition of micro flora in 1 g of tissues, in farm animals, with accidental wounds was up to 105 . The appliance of wound dialysis gave rapid destruction of associations of 2 and 3 types of microorganisms, in contrast to the control group of animals. The effect of applying membrane dialysis devices, in case of accidental wounds, allows to achieve positive results for 3-4 days. Bacteriological studies confirm the high antibacterial activity of dialysate, which was provided by the introduction of antibiotics and antiseptics into its composition. The introduction of antibiotics and antiseptics into the membrane drainage cavity once a day in the amount of a single therapeutic dose, allows for 7.1±1.3 days (P>0.001) to suppress the microflora in the wound. Higher antiseptic effectiveness of dialysates from semipermeable membranes is connected with their ability to create a constant high concentration of antibacterial substances in the wound focus. The mechanism of therapeutic effect is in a gradual and constant flow of antiseptics into the paravulnar tissues, by diffusion. This improves the conditions for the development of the body’s own phylactic power against infection and raises regenerative processes in the wound.
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