Abstract
Even today, few transplantable bone-forming osteosarcomas are available. Therefore, we tried to produce such tumors experimentally in the bone of rats with administration of 4 NQO and/or 32P. The results were as follows:1) No malignant bone tumor developed in 100 g rats with a single administration of 4 NQO into the mandible and femur in doses of 2 or 4mg per body weight.2) Combined administration of 32P (2.8μci/g) with 4 NQ0 (0.17-1mg/100g) produced tumors in 77 out of 87 rats. Histologically tumors were classified as osteosarcoma (78.0%), fibrosarcoma (15.8%) and others. The locally inoculated 4 NQO showed less inductivity of osteosarcoma, but increased producing of fibrosarcoma.3) Several characteristics of induced osteosarcomas were observed: Osteosarcomas with higher ossification had a longer doubling time and a higher incidence of lung metastasis and a higher value of serum alkaline phosphatase were observed. These findings could serve clinical diagnosis and therapy of human osteosarcomas.4) Three transplantable osteosarcomas (MSU-A 3, -D 16, -E 3) in vivo and one osteosarcoma cell line (MSK) in vitro were established. These strains and one cell line showed a marked osteoid forming activity when they were inoculated subcutaneously into the back of F 344 rats. We believe that these tumors would be very useful as a model of osteosarcomas.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Japanese Journal of Oral & Maxillofacial Surgery
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
