Abstract
The objective of the study: to evaluate the safety and efficacy of the combination drug of hydroxymethylquinoxalinedioxide + isoniazid lyophilisate within chemotherapy of patients with bronchial tuberculosis complicating pulmonary tuberculosis. Subjects and methods . Adverse effects of the combination drug were studied in 26 patients with bronchial and pulmonary tuberculosis who had inhalations with hydroxymethylquinoxalinedioxide + isoniazid lyophilisate. The treatment efficacy of bronchial tuberculosis was compared in Group I (24 patients who received basic therapy for tuberculosis and inhalation) versus Group II (34 patients who received basic therapy only). Results. Adverse events occurred in 4/26 patients (15.4%, 95% CI 5.5-34.2%) who had inhalations with a solution of hydroxymethylquinoxalinedioxide + isoniazid lyophilisate due to bronchial tuberculosis, 2/26 (7.7 % 95% CI 1.0-25.3%) had to have the drug discontinued. Treatment efficacy of bronchial tuberculosis was statistically significantly higher in patients from Group I (based on endoscopy data) compared to Group II (after 1 month of treatment, 20/24 (83.3%) and 14/34 (41.2%), respectively; p = 0.001 Fischer’s Exact test; after 6 months 23/24 (95.8%) and 26/34 (76.5%), respectively; p = 0.041 Fischer’s Exact test).
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