Abstract
健常者,慢性関節リウマチ患者および肝細胞癌と転移性肝癌患者の血清sialyltransferase (ST)活性を等電点電気泳動法で分析した.血液凝固時に生ずる血小板STの混入を除去した血清をAmpholine (pH 3～10)を含む等電点カラム電気泳動法で分画し,酵素活性はasialofetuinをacceptorとして測定した.健常者の血清にはpI 4.40, 6.65および7.00の3つのST活性が認められた.肝癌患者の血清では,肝細胞癌でpI 7.90と8.30,転移性肝癌ではpI 7.90と8.20に異常ST isoenzyme活性が認められた.慢性関節リウマチ患者の血清ではpI 7.90～8.30域にST活性は認められなかった.
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