アテローム血栓症のイベントリスクに関する国際観察研究―ＲＥＡＣＨ Ｒｅｇｉｓｔｒｙ―

Abstract

REACH Registry is a large international observatioal study in patients with symptomatic atherothrombosis including cerebrovascular disease (CVD), coronary artery disease (CAD), and peripheral artery disease (PAD) as well as asymptomatic patients with multiple risk factors for atherothrombosis. We analyzed the baseline and one-year follow-up data on the risk of CVD in 5,197 Japanese patients enrolled in the REACH Registry.Except advanced age, hypercholesterolemia and diabetes under drug treatment as well as carotid plaque were frequent risk factors even more than uncontrolled hypertension in the Japanese CVD patients. One-year follow-up data showed that cardiovascular (CV) death and total CV events were highest in CVD patients and lowest in CAD patients. The incidence of CV events was higher in patients with CVD plus PAD than CVD alone. The incidence of CVD was very high in patients with carotid stenosis or plaque, PAD, and diabetic nephropathy.We clarified in this study that in CVD patients the risks of death and CV events are highest among patients with atherothrombosis. In order to reduce these risks, we may need strict management of not only hypertension but also hyperlipidemia and diabetes as well as strategies against carotid disease and PAD.