Abstract
Chitin has been used as a temporary dressing material for dermal wounds. The properties of chitin for wound repair include hemostatic, analgesic, wound drying, and wound-healing accelerating effects. However, few studies have reported the use of chitin in the oral cavity. In order to investigate the mechanisms of these favorable properties, the influence of chitin on the oral tissue was analyzed as described below. In this study, chitin was tested for its capacity to induce fibronectin production and human gingival fibroblast-like cell (HGF) migration from human peripheral monocytes, and compared with lyophilized porcine dermis (LPDS) and collagen wound dressing (CAS). Fibronectin and HGF chemotactic activity in the supernatants of HGF (FCM) cultured on chitin, LPDS and CAS were examined. Furthermore, macrophage conditioned medium (MCM) was added to HGF culture on each wound dressing material, and the supernatants were examined in a similar manner. Fibronectin production by macrophages was highest when the cells were cultured on LPDS. On the other hand, when MCM was added to the HGF culture on chitin, fibronectin production was strongly induced. When all supernatants were cultured on chitin, HGF chemotaxis was more active than any other material.
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