Abstract
The aim of the study was to investigate the antioxidant activities of ethanol extract of perilla seed (PSE) and its inhibitory effects against major characteristics of cancer cells, such as unrestricted growth and activated metastasis in vitro. The total polyphenol and flavonoid levels of PSE were 222.6 mg gallic acid equivalent/100 g and 285.7 mg quercetin equivalent/100 g, respectively. The radical scavenging activity and ferric reducing antioxidant power of PSE at concentration of 87.5 to 350 μg/mL were 24∼45% and 28∼62%, respectively. Treatment of HCT116 colorectal carcinoma cells and H1299 non-small cell lung carcinoma cells with PSE dose-dependently inhibited growth by 18∼94% (at concentration range of 87.5 to 350 μg/mL) and completely abolished colony formation (at concentration of 175 μg/mL). PSE was also effective in inhibiting migration of H1299 cells (by 30∼37% at concentration range of 87.5 to 350 μg/mL) and adhesion of both HCT116 and H1299 cells (by 14∼16% at concentration of 350 μg/mL). These results indicate that PSE exerts antioxidant and anti-cancer activities in vitro. It needs to be determined whether or not similar effects can be reproduced in vivo.
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