여주 초음파 추출물의 항산화, 항당뇨 및 항염 활성

Abstract

We obtained polyphonol extracts from bitter melon containing various bioactive compounds to improve applicability as functional food materials. The total phenolic content (TPC), antioxidant, antidiabetic, and anti-inflammatory activities of bitter melon extracts obtained using various extraction methods were compared. The extracts obtained using ethanol as the solvent had a higher TPC than extracts obtained using water. The extracts obtained using ethanol also had high antioxidant, antidiabetic, and anti-inflammatory activities when performed using ultrasonic-assisted extraction (UE) with ethanol. The extract obtained using probe type-UE with ethanol (PUE-E) exhibited α-amylase and α-glucosidase inhibitory activity levels corresponding to 90% or more of acarbose (a diabetes treatment). An extract obtained using a bath type-UE with ethanol (BUE-E) exhibited high NO inhibitory activity at all concentrations. Therefore, UE with ethanol is a very effective method for recovering polyphenol extracts from bitter melon with antioxidant, antidiabetic, and anti-inflammatory activities. In addition, the polyphenol extracts obtained from bitter melon by UE with ethanol (especially PUE-E and BUE-E) have a high application potential as functional food materials.