ИЗУЧЕНИЕ ВЛИЯНИЯ БАРИАТРИЧЕСКОЙ ХИРУРГИИ НА ПРОДОЛЖИТЕЛЬНОСТЬ ЖИЗНИ ПАЦИЕНТОВ С МЕТАБОЛИЧЕСКИМ СИНДРОМОМ

Abstract

Introduction: A correlation was found between the length of chromosome telomeres as a predictor of life expectancy and obesity with metabolic manifestations. The aim of this study was to evaluate the changes of telomere length as an indicator of life expectancy, changes in body mass and other components of the metabolic syndrome after weight loss. Methods: the study is designed as an interventional, prospective, controlled, a three-arm randomized controlled trial at a single center including 60 participants. The first group is composed of patients who have undergone stapleless laparoscopic one anastomosis gastric bypass with an obstructive stapleless pouch and anastomosis. The second group of patients underwent staple use laparoscopic mini-gastric bypass-one anastomosis gastric bypass. The patients in the third group received non-surgical weight loss therapy, including a hypocaloric diet with energy restriction. Primary outcome measures included changes in the length of leukocyte telomeres. Secondary outcome measurements included changes in body mass index, other components of the metabolic syndrome. Results: 60 patients were randomized and allocated for intervention: first group (n=20), second group (n=20), third group (n=20). The surgical groups (first, second) after 12 months postop had the greatest weight loss compared to third group with average changes BMI. The surgical groups also had the most significant change in telomere length. Conclusions: Compared with the non-surgical treatment of obese patients with metabolic syndrome, bariatric surgery leads to greater body weight loss and a significant increase in telomere length and greater resolved metabolic syndrome.