Abstract
세신은 한약재로써 오랫동안 사용되어 왔으며 해열, 진정, 진통, 항염증, 면역억제작용등을 나타낸다. 세신에서 증기증류법으로 추출한 정유를 이용하여 이의 항진균 활성을 조사하였다. 세신의 정유는 Aspergillus niger, A. fumigatus, Candida albicans 그리고 Cryptococcus neoformans 등의 피부진균 및 기회감염균에 대하여 높은 항진균 활성을 나타내었다. C. albicans에 대한 최소억제 농도는 약 5 ul/ml로 매우 적은 양으로 높은 억제 효과를 보였으며 이를 바탕으로 천연항균제 또는 천연방부제로 식품 및 화장품에 첨가제로 사용할 수 있는 가능성을 보여주었다. Root of Asarum sieboldii has been used in chinese medicine. It was been known that the extract of A. sieboldii has medicinal effect such as antifebrile, anodyne, and anti-inflammatory. Antifungal activity of the essential oil extracted from A. sieboldii against various epiderman and opportunistic human pathogenic fungi was investigated. Steam-distillated essential oil demonstrated very high antifungal activity against Aspergillus fumigatus, Aspergillus niger, Cryptococcus neoformans, and Candida albicans. MIC (minimum inhibitory concentration) of the essential oil against C. albicans was 5 ul/ml, indicating that the essential oil may be used as natural preserves for cosmetic and nutritional products.
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