Abstract
The aim of the present study was to investigate the effect of Clostridium butyricum, a probiotic drug, when combined with vancomycin in the treatment of Clostridium difficile-associated diarrhea (CDAD). Seventy-one patients suffering from CDAD were divided into 3 groups : vancomycin alone group, vancomycin with Streptococcus faecalis group and vancomycin with Clostridium butyricum group. The daily stool frequency for patients receiving vancomycin alone at 2 days was 3.9/day. For patients receiving vancomycin with C. butyricum, this parameter was significantly lower than in the vancomycin alone group (p<0.05) but this was not so for the vancomycin with S. faecalis group. In addition, the treatment period with vancomycin was reduced when it was co-administered with the C. butyricum probiotic drug.These results indicated that the combination of vancomycin and C. butyricum had a beneficial effect in the treatment of CDAD.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
